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  1. ... Advanced Search New Results A versatile two-step CRISPR- and RMCE-based strategy for efficient genome engineering ... History Metrics Preview PDF Abstract The development of CRISPR/Cas9 technologies promises a quantum leap in genome- ...
  2. ... identified CRISPR spacers in the metagenomes with two different methods and found more spacers in the IC21 and C34 salterns compared with the SS19, SS33, and SS37 salterns, suggesting fewer types of CRISPR spacers ... //... their low microbial diversity, environmental stability, and high viral density. By using the power of CRISPR spacers to link viruses to their prokaryotic hosts, we explored virus-host interactions in geographically ...
    Date: 1969-12-31T19:00:14-0500
  3. the ongoing malaria elimination campaign. Methods Generation of CRISPR/Cas9 pmt knock-out cell line To disrupt ...
  4. the only validation initiative put forward to identify non-specific antibodies4. CRISPR and other gene ...
  5. ... Selection of chromosomal DNA libraries using a multiplex CRISPR system in Saccharomyces cerevisiae Owen W Ryan , Jeffrey ... step and marker-free genome editing system using CRISPR-Cas9. With this Multiplex CRISPR (CRISPRm) system, we ...
  6. ... The recent development of the CRISPR-Cas9-based gene drive has created the conditions to seriously consider this technology to solve one of the major environmental challenges in biodiversity conservation i.e. the ...
    Date: 1969-12-31T19:00:12-0500
  7. knock-down of Nav1.7 will not be possible, and the possibility of CRISPR-mediated gene knockout (in ... small molecules to mimic Nav1.7 gene deletion will be problematic. Nociceptor silencing through CRISPR ...
  8. genes7,8. A recent genome-scale CRISPR screen in a related apicomplexan parasite Toxoplasma gondii has ...
  9. ... Info/History Metrics Data Supplements Preview PDF Abstract CRISPR-based genome editing is an enabling technology with ... this technology. A novel Type V, Class 2 CRISPR nuclease system was identified from Microgenomates and Smithella ...
  10. ... rearrangements in Y. pestis. We also reconciled phylogenetic trees for each of the three CRISPR-loci to obtain an integrated scenario of the CRISPR-cassette evolution. We detected numerous parallel inversions and gain/loss events ... //... resolution of phylogenetic reconstruction. In contrast, reconstructions of strain relationships based on solely CRISPR loci may not be reliable, as the history is obscured by large deletions, obliterating the order of spacer ...
    Date: 1969-12-31T19:00:05-0500
  11. Both targeted traps (tm1a) and null (tm1b and CRISPR induced deletions) alleles are employed ... insertion allele, compared with 20 containing exon deletions (19 tm1b and 1 CRISPR). With either group ...
  12. such as the CRISPR-Cas gene editing technology, may encourage some to “play God” due to their supposed capability ...
  13. ... RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can reveal the basic blueprint ... framework for understanding the capabilities and limitations of CRISPR technology, we derive gold-standard reference sets of ...
  14. ... CRISPR/Cas9 is emerging as one of the most-used methods of genome modification in organisms ranging from bacteria to human cells. However, the efficiency of editing varies tremendously site-to-site. A recent report ...
    Date: 1969-12-31T19:00:20-0500
  15. and thus generally represent a particularly amenable tool for CRISPR-Cas9 mediated genome editing ...
  16. siRNA small interfering RNA, CRISPR clustered regularly interspaced short palindromic repeats, shRNA ...
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