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Other Aliases: CG10873, CG31325, Dm-P53, DmP53, Dp53, prac, Dmel\CG33336, CG33336 Organism: Drosophila melanogaster Chromosome: 3R y[1]; cn[1] bw[1] sp[1]; Rh6[1] Other Designations: p53, isoform B, CG33336-PB, p53-PB, p53-like regulator of apoptosis and cell cycle, p53, isoform A, CG33336-PA, p53-PA Location: 94D10-94D10 Other Aliases: dp53, Dmp53, CG10873 Organism: Drosophila melanogaster Chromosome: 3R y[1]; cn[1] bw[1] sp[1]; Rh6[1] Other Designations: CG10873-PA Location: 94D10-94D10 Offical Name: tumor suppressor protein p53 Other Aliases: p53 Organism: Oryzias latipes Other Designations: tumor suppressor protein p53 Offical Name: tumor suppressor p53 Other Aliases: P53, TP53 Organism: Sus scrofa Chromosome: 12 Other Designations: tumor suppressor p53 Location: 12q12-q14 Organism: Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) Chromosome: USA:Madison, WI secondary endosymbiont of aphids Other Designations: APSE-2 prophage; hypothetical Organism: Bacteriophage APSE-2 Chromosome: USA:Madison, WI Other Designations: hypothetical protein Offical Name: transformation related protein 53 Other Aliases: bbl, bfy, bhy, p53 Organism: Mus musculus Chromosome: 11 Other Designations: transformation related protein 53, tumor supressor p53, p53 cellular tumor antigen Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq] Location: 11 B2-C Offical Name: tumor protein p53 Other Aliases: p53, brp53, drp53, fb40d06, wu:fb40d06, zgc:111919 Organism: Danio rerio Chromosome: 5 Other Designations: tumor protein p53, etID22686.5, cellular tumor antigen p53, tumor suppressor homolog p53 Offical Name: tumor protein p53 Other Aliases: p53, Trp53, MGC112612 Organism: Rattus norvegicus Chromosome: 10 Other Designations: transformation related protein 53, p53 tumor suppressor, tumor protein p53 (Li-Fraumeni syndrome) Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Alternatively spliced transcript variants have been found for this gene, but the biological validity of the variants has not been determined. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq] Location: 10q24 Offical Name: tumor protein p53 Other Aliases: p53, LFS1, TRP53, FLJ92943 Organism: Homo sapiens Chromosome: 17 Other Designations: tumor protein p53, p53 antigen, phosphoprotein p53, p53 tumor suppressor, p53 transformation suppressor, transformation-related protein 53 Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq] Location: 17p13.1 Offical Name: tumor protein p53 Other Aliases: TP53, P53 Organism: Ovis aries Other Designations: P53 protein Offical Name: tumor protein p53 Other Aliases: TP53, P53 Organism: Canis lupus familiaris Chromosome: 5 Other Designations: tumor protein p53, tumor suppressor protein, tumor protein p53 (Li-Fraumeni syndrome) Offical Name: tumor protein p53 Other Aliases: p53, Xp53, lfs1, trp53, MGC75630, MGC79985 Organism: Xenopus (Silurana) tropicalis Other Designations: tumor protein p53, Li-Fraumeni syndrome Offical Name: tumor protein p53 Other Aliases: tp53, p53 Organism: Oncorhynchus mykiss Other Designations: tumor protein p53, tumor suppressing protein Offical Name: tumor protein p53 Other Aliases: TP53, p53 Organism: Monodelphis domestica Chromosome: 2 Other Designations: tumor protein p53, tumor protein p53 (Li-Fraumeni syndrome) Offical Name: Wistar clone pR53P1 p53 pseudogene Other Aliases: p53 Organism: Rattus norvegicus Chromosome: 9 Location: 9q13 Offical Name: beta-Tubulin at 60D Other Aliases: 143391_i_at, 3t, B3t, BETA 60D, D.m.BETA-60D, DTB3, Dmbeta3, T, Tub, beta-Tub60D, beta-Tub6D, beta-tub, beta3, beta3 TU, beta3-Tub, beta3t, beta60C, betaTub3, betaTub60C, beta[[3]] tubulin, beta[[3]]-Tub, beta[[3]]-tubulin, p50, p50/tubulin, p53, p53/tubulin, Dmel\CG3401, CG3401 Organism: Drosophila melanogaster Chromosome: 2R y[1]; cn[1] bw[1] sp[1]; Rh6[1] Other Designations: beta-Tubulin at 60D, CG3401-PA, betaTub60D-PA, beta-3 tubulin, beta3-tubulin, beta 3 tubulin, beta3 tubulin, beta3tubulin, beta-Tubulin, beta tubulin, beta-3tubulin, b-3 tubulin, beta-3-tubulin, tubulin b-3, tubulin, 60C beta tubulin, B3-tubulin Location: 60C6-60C6 Offical Name: transformation related protein 53, pseudogene Other Aliases: p53 Organism: Mus musculus Chromosome: 17 Location: 17 C Offical Name: homothorax Other Aliases: 1323/07, 1422/04, Dm-HTH, Hth, Meis1, P53, anon-EST:Liang-2.13, clone 2.13, dtl, hth1, hth2, l(3)05745, l(3)86Ca, Dmel\CG17117, CG17117 Organism: Drosophila melanogaster Chromosome: 3R y[1]; cn[1] bw[1] sp[1]; Rh6[1] Other Designations: homothorax, isoform A, CG17117-PA, hth-PA, dorsotonals, homothorax, gene II, homothorax, isoform B, CG17117-PB, hth-PB, homothorax, isoform C, CG17117-PC, hth-PC, homothorax, isoform D, CG17117-PD, hth-PD, homothorax, isoform E, CG17117-PE, hth-PE, homothorax, isoform F, CG17117-PF, hth-PF Location: 86C1-86C3 Offical Name: HLA complex P5 pseudogene 3 Other Aliases: P5-3, P5.3, P5-03 Organism: Homo sapiens